Main House
Step into history at The Main House 401, a beautifully preserved 1929 home in Blacksburg’s historic district. Featuring three charming guest rooms—The Appalachian (Queen Junior Suite), The Smithfield (King Room), and The Blue Ridge (Queen Room)—this inviting retreat offers both relaxation and sophistication. The first floor provides a welcoming space for meetings or leisurely afternoons.
For complete privacy, book the entire house and enjoy exclusive access. Call or email for pricing and availability!
Coffee
Machine
COMPHY Branded Sheets
Private
Bathroom
Bathrobes & Hairdryer
Electric
Fireplace
HD Flat Screen Apple TV
Highspeed
WiFi
Truffle/
Candy Gift
Room 7
Appalachian Queen
Junior Suite
Our most requested guest room, The Appalachian, offers a warm and inviting retreat with a separate pine-paneled sitting area. Enjoy natural light from the skylight and scenic views from the second-floor windows. Relax in the private bath featuring both a tub and shower—your perfect escape in historic Blacksburg.
Room 8
Smithfield King
Our most requested guest room, The Appalachian, offers a warm and inviting retreat with a separate pine-paneled sitting area. Enjoy natural light from the skylight and scenic views from the second-floor windows. Relax in the private bath featuring both a tub and shower—your perfect escape in historic Blacksburg.
Room 9
Blue Ridge Queen
Bathed in soothing Blue Ridge hues, this inviting corner room on the second floor offers a peaceful retreat. With the option for an additional bed and a private bath featuring both a tub and shower, it’s the perfect blend of comfort and charm—one stay, and you’ll want to return!
Stay in Comfort, Steps from Downtown
Discover Blacksburg Bed & Breakfast, a charming retreat at 401 Clay Street SW. With nine elegantly appointed guest rooms across three connected homes, we offer the warmth of a B&B with the luxury of an upscale hotel.